Asante Kotoko will play away in the Round of 64 in the MTN FA Cup after the second round draw was made on Wednesday.
The second round matches will be played between December 18-23.
Wednesday's draw saw the sixteen premier league sides who joined the Cup competition after drawing a bye during the preliminary round matches all kept apart.
The Porcupine Warriors, two-time losing finalist in the last three season's will attempt to progress to the next round when they meet either Tamale Liberty or Waiga United, both third-tier sides.
Reigning champions, Medeama's title defence starts with an away fixture against another third-tier team, Score FC.
Hearts of Oak were paired with Division One side, Gold Stars.
The team that emerges as winner of the MTN FA Cup competes in the CAF Confederations Cup.
Round of 64 Pairings
Inter Allies vs Berlin FC
Mighty Jets vs Mepe United
Tarkwa United vs Hearts of Lions
Rospac FC vs Right to Dream FC
Bubiashie Charity Stars vs Liberty Professionals
Dawhyenya FC / Royal Faith vs Bazooka FC
Metro FC vs Esperance
New Edubiase vs Bolga Man City
Ebusua Dwarfs vs First Klass FC
Tamale Liberty/Waiga Utd vs Asante Kotoko
Future Stars vs Bofoakwa
Okwahu United vs Real Athletico
Bolga All stars/Crystal Palace vs Believers FC
Nania FC vs DC United
Aduana Stars vs Asokwa Deportivo / Dunkwa United
King Faisal vs Tuobodom Santos
Real Tamale United vs UCC Youngsters
Feyenoord Academy vs Wa All Stars
Red Lions FC vs Binduri United
Berekum Chelsea vs Wenchi United
Gold Stars vs Accra Hearts of Oak
Starke FC vs Hasaacas
Kessewa International vs Kotoku Royals
Prestige FC vs Istanbul FC
Ash Gold vs BA United
Amidaus Professionals vs Danbort FC
Score FC vs Medeama
Sampa United vs Bagotek
Tumu Happy Stars vs Tema United
Dolphins FC vs Guan United
Pure Joy vs Ajax Fc
Bechem United vs Cape Coast Strikers