Coach Avram Grant's side seek to make their fifth successive appearance at the semi finals stage of the African Cup of Nations when Ghana take on Guinea on Sunday.
The two sides met in qualifiers, with the Black Stars having the edge thanks to a 1-1 draw and then a 3-1 victory at home.
The Guineans qualified to this stage of the tournament after winning a draw of lots on Thursday to emerge from Group D at the expense of Mali.
Whiles the Black Stars of Ghana finished top of a tough group ahead of Algeria, Senegal and South Africa.
Guinea who drew 1-1 in all three group games are aiming to go beyond the quarter-finals for the first time since the Cup of Nations was expanded to 16 teams in 1996.
Captain Asamoah Gyan and his teammates are also targeting a win that will set a semi-final match against the winner of the quarter-finals game between hosts Equatorial Guinea and Tunisia.
The Syli Nationale will be without Florentin Pogba who has already left the Guinea squad because of a groin injury with captain Kamil Zayatte yet to feature at the finals due to a calf problem.
Stand-in skipper Ibrahima Traore is expected to play despite coming off in the match against Mali.
For the Black Stars, defender Daniel Amartey could return to full fitness after coming off early in the 2-1 defeat of South Africa on Tuesday.
The match which will be handled by Zambian referee Janny Sikazwe, is scheduled to kick off at 16:00 at the Estadio de Malabo.