Asamoah Gyan and Mubarak Wakaso? have pulled out of Ghana's return game against Mozambique in the 2017 Africa Cup of Nations qualifying.
The duo did not travel with the 21-man playing squad that departed Accra on Friday for the game on Sunday.
Gyan did not play a part in the first leg after he suffered a thigh injury in the build up to the game.
However, Wakaso, who featured in the 3-1 victory was withdrawn as the game progressed.
Ghana are leading the log in Group H after picking up their third-straight win. And victory in Maputo would confirm their place at next year's finals in Gabon.