Jeffrey Schlupp is set to make his competitive home debut in Saturday afternoon's 2015 Africa Cup of Nations qualifier against Uganda in Kumasi.
Black Stars coach Kwesi Appiah selects the Leicester City player at left-back as Ghana open the Group E opener at the Baba Yara Stadium at 16:00GMT.
Captain Asamoah Gyan leads the line for Ghana and will be partnered by Majeed Waris for the clash against the Cranes.
Ghana XI :
Fatau Dauda, Harrison Afful, Jeffrey Schlupp, John Boye, Jonathan Mensah, Rabiu Mohammed, Christian Atsu, Kwadwo Asamoah, Asamoah Gyan, Majeed Waris, Andre Ayew