The league title could be decided on Saturday at the Baba Yara Stadium if Asante Kotoko manages a win in their match-day-27 clash in the OneTouch Premier League.
Asante Kotoko would be at home to Real Sportive as they try to overcome the painful midweek loss as they were beaten 2-0 by bottom-placed, Great Olympics.
The Porcupine Warriors sit at the summit with a 10-point gap and could clinch the title if they pick all three points, with 12 points left to play for in the league.
But as Kotoko look to seal the title, Great Olympics would have to maintain their winning run and hope others caught up in the bottom ranks slip, if they are to avoid the drop.
The Wonder Boys chalked a second successive win this season after beating Kotoko and would have to extend that winning run up North, where they play Real Tamale United at the Tamale Sports Stadium.
Sekondi Hasaacas, who lie two places from the bottom of the table, will also need to win away from home as they travel to Kpando, where they clash with Heart of Lions, placed second on the table and seeking a Champions League spot.
Tema Youth would need to improve their standing on the table to avoid the drop as they come up against Liberty Professionals, who have their sights set on the second Champions League place after missing out of the title chase.
At the Golden City Park, AshantiGold will test the home invincibility record enjoyed by Berekum Arsenals when both sides meet while Zaytuna FC, serving a three-match home ban, take on Wa All Stars at the Coronation Park in Sunyani.
Hearts of Oak, still on the winning road would come up against King Faisal at the Ohene Djan Stadium.
And at the Anane Boateng Stadium, Kessben FC will host Gamba All Blacks.