Asante Kotoko were in superior form as they thrashed neighbours AshantiGold 3-0 in a late kick off at the Baba Yara Stadium.
Michael Akufo and Nathaniel Asamoah both scored in the first half to set the Porcupine Warriors on their way to victory before Michael Anaba added the third goal with three minutes left on the clock.
Though it is still early days in the competition, the win places Kotoko among the top-four side while the Miners slump to 13th on the table.
Life after Bashir Hayford presented Medeama with nothing new as the Tarkwa side slumped to their second league defeat on Sunday.
With Hayford placed on leave after their league opener, Medeama were expecting better luck as Yusif Abubakar led the side to the Agyeman Badu Park where they lost 1-0 to Aduana Stars.
Emmanuel Akuoko's second half goal condemned Medeama to defeat as they sit a place above the bottom side.
A late Emmanuel Baffour goal handed New Edubiase all the spoils in their game with Heart of Lions at the Gyamfis Park as they won 1-0.
The win secures top spot for Edubaise after match-day-2 as Baffour now has four goals in the competition.
The derby in Accra went the way of the Rainbow side as Hearts of Oak recorded their second win in the league after beating Mighty Jets 2-1 at the Accra Sports Stadium.
The Phobians raised into a two-nil through Douglas Nkrumah from the spot in the 34th minute and Uriah Asante after 58 minutes.
But Jets who reduced to 10 men following the dismissal of Hassan Mohammed managed to pull one back through Inusah Musa in the 74th minute.
Newboys Wassaman earned their first victory in the elite division after beating Berekum Arsenal 2-1 at Sekondi.
Jordan Mintah and substitute Paul Danso scored Wassaman while Prince Adjei got a consolation for Arsenal.
Wa All Stars kept their impressive start to the season going at home where they defeated Tema Youth 1-0 courtesy Frank Sarfo Gyamfi's 53rd minute goal.
Seidu Bancey grabbed a brace to help Ebusua Dwarfs to a 2-0 home win over Bechem United, who finished with a man down at the Robert Mensah Stadium.
Both goals came from the spot.
Earlier on Saturday, Berekum Chelsea beat Liberty Professionals 2-1 at the Golden City Park.
A last-gasp goal by substitute Yaw Alexander handed Chelsea the winner after Abdul Basit had cancelled out Fuseini Zuberu's opener.