Ghana will face South Africa, Zimbabwe and Ethiopia in the 2nd round qualifiers of the Qatar 2022 Fifa World Cup.
The Black Stars were handed another South African challenge following Tuesday's draw by the Confederations of African Football in Egypt.
The Black Stars are already in the same qualifying group with South Africa for the 2021 African Cup of Nations in Cameroon.
Ghana defeated South Africa 2:0 in the opening match of the 2021 Afcon qualifier in Cape Coast in November last year and with the return encounter yet to be played, the latest draw renews the growing rivalry between Ghana and South Africa.
Tuesday's draw saw 40 African countries placed into 10 groups of 4 countries and only the ten group winners will advance to the 3rd and final round of qualifiers.
At the final round, the ten group winners will be split into two and paired for a two-leg, home and away encounters.
Winners of the two-leg matches will qualify to the World Cup in Qatar.