Ghana has suffered a 2-1 defeat in their 2015 AFCON Group C opener against Senegal in Mongomo.
A late Senegal strike by Moussa Sow in the 93rd minute denied the Black Stars a share of the spoils.
Captain Andre Ayew put Ghana in front after converting a first half penalty following a foul on Christian Atsu by goalkeeper Coundoul in 13th minute.
Ghana ended the opening half in the lead.
However, Senegal returned from the break much stronger and succeeded in getting the equalizer through Mame Diouf in the 58th minute.
Avram Grant's side will play Algeria on Friday before taking South Africa in their final group stage match.