Leaders Chelsea have ended Asante Kotoko's fine start to the second round as they beat the Porcupine Warriors 1-0.
Striker Emmanuel Clottey scored the winner in the first half ending Kotoko's three-game winning run. Chelsea have now opened a 11-point lead at the top ahead of the midweek fixtures.
In Accra, Hearts of Oak's mini revival was short-lived following defeat to Heart of Lions.
Former Hearts attacker, Gilbert Fiamenyo struck the goal to hand the Kpando side a 1-0 victory.
Champions Aduana Stars posted a 1-0 victory over AshantiGold to move second on the standings and 11 point adrift the summit.
All Stars' poor run continued at the Robert Mensah Stadium where they lost 1-0 to Ebusua Dwarfs. Emmanuel Ackon scored the only goal for Dwarfs as the Blues' six-game winless run continues.
Emmanuel Odoi scored to hand King Faisal a 1-0 win against Berekum Arsenals at the Baba Yara Stadium.
Goals from Lousi Agyemang and Emmanuel Dogbe secured Kessben FC a 2-1 home win over Real Tamale United. The win halts RTU's impressive run in the second round of the league.
Mighty Jets claimed a share of the spoils in their goalless draw with New Edubiase at the Gyemfis Park.
Liberty Professionals pushed themselves out of the relegation zone after beating bottom side, B.A. Stars 2-0 in the evening fixture of the weekend played at the Len Clay Stadium.
Dwarfs 1- 0 All Stars
Chelsea 1- 0 Asante Kotoko
Edubiase FC 0-0 Mighty Jets
Aduana Stars 1-0 AshantiGold FC
Hearts of Oak 0-1 Heart of Lions
King Faisal 1-0 Arsenals
Kessben FC 2-1 Real Tamale United
BA Stars FC 0-2 Liberty Professionals