Fresh from an exciting four-week break, premiership clubs would be seeking to cut out the African Nations Cup hangover as the second round Glo Premier League begins in midweek.
The prospect of Aduana Stars holding onto the top spot would tested on the opening day of the league's second round as they travel to the Len Clay Stadium to face AshantiGold in match-day-16.
AshantiGold, one of the league's six sides who have gone unbeaten in the first round would attempt to maintain their record when they debutants visit them at home.
Second-placed All Stars take on Great Olympics at the Ohene Djan Stadium.
The second half of the season might bring good tidings for Asante Kotoko who have struggled to convince their followers of annexing the title.
Kotoko, lying seventh would host fourth placed, Kessben FC at the Baba Yara Stadium.
Champions, Accra Hearts of Oak would be away to Real Tamale United at the Tamale Sports Stadium as they keep the pressure at the top.
The Phobians are one-point adrift the leaders and would be hoping to pick all three points.
Berekum Arsenals would be at the Golden City Park where they host New Edubiase while Heart of Lions take on King Faisal at the Kpando Park.
Struggling Eleven Wise would attempt to lift themselves off the bottom of the table when they line up at home to Chelsea.
Bottom side, Hasaacas would travel to the Carl Reindorf Park to play Liberty Professionals.