Defending champions Asante Kotoko have been paired with Division One League side Future Stars in the Round of 64 of the MTN FA Cup, as revealed at the draw on Friday, November 14, 2025. Two-time winners Medeama SC will face Rospak FC, while Sekondi Eleven Wise has been paired with Premier League side FC Samartex 1996. Record holders Accra Hearts of Oak will square off against third-tier side True Life FC, and Na God FC and Dreams FC will face Accra Great Olympics and Semper FI, respectively.
These matches will be played on the weekend of November 25-27, 2025:
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