Real Tamale United started off life in Division One on a winning note but the same did not apply for Tema Youth and Berekum Arsenal as the competition started in the second-tier ranks.
Former premiership campaigners, Great Olympics won on the first day as they go top of Zone 3A.
Below is the full list of results on the opening day:
Zone 1A
Wa African Utd. 2-1 Utrecht Dynamos 1-0 Bazooka Guan 1-3 R.T.U. Bolga All Stars 0-0 Galazy
Zone 1B
Berlin 2-0 Esperance B. A. United 2-0 Berekum Arsenal Unity F.C 3-2 Bofoakwa
Zone 2A
Kfc Samosa 2-1 Red Lions Tarkwa United 1-1 Gold Stars Dunkwa United 2-0 Starke Rainbow 0-1 Asokwa Deportivo
Zone 2B
Samin 1-0 Windy Profs. Metro 0-3 Eleven Wise Elmina Sharks 2-3 Feyenoord Aca Ajax F.C 1-0 Wassaman . Zone 3A
Sporting Mirren 2-0 Great Warriors Istanbul 0-0 Nania Prestige 0-1 D’international Gt. Olympics 2-0 Real Athletico
Zone 3B
Danbort 1-0 Tema Youth Okwawu Utd. 2-0 King Solomon Pure Joy 1-0 Zaytuna Mighty Jets 0-0 Fairpoint