Amidaus Professionals face a nervy finish to their second season in the top-flight after dropping into the relegation zone following defeat to Wa All Stars on Sunday.
The Tema-side were beaten 2-0 in Wa as the Blues who are still struggling to pull away from safety.
Goals in either half helped Wa All Stars to the home win as Michael Mensah opened the scoring in the 8th minute before Asuandzie Baffoe doubled their lead after 54 minutes.
At the T&A Park, Medeama's hopes of finishing second suffered another hit after they were held to a goalless draw by King Faisal.