Junior Agogo returned from injury to score the winning goal for Zamalek as he made his league debut for the Cairo side.
Zamalek finished the game 2-1 winners over El Masry with Agogo striking the match winner in the second half.
Agogo has missed the first two games of the Egyptian domestic season with a knee injury.
The goal which proved to be the winner would come as major boost for the Ghana international after completing his big money move from Nottingham Forest this season.