Asante Kotoko and Hearts of Oak both face tricky ties after the draw for the Round of 64 games in the MTN FA Cup was made on Tuesday.
The live draw entered 16 Premier League clubs, 24 Division 1 Clubs and 24 Division 2 clubs.
Kotoko will be home to either Japekrom Mpuasuaman or Dormaa Nkyenkyenkye, both third-tier teams in the second round stage of the Cup competition while Hearts of Oak travel to Tamale to face Utrecht.
Champions New Edubiase will be away to Starke FC in Sekondi.
The matches of the Round of 64 will start from Thursday, February 14, 2013.