Heart of Lions are the first premier league side to kick in the Round of 64 of the MTN FA Cup when they play Yagbon Stars.
Ten games will come off Thursday as the premiership campaigners travel to the Berekum Golden City.
A number of former elite sides will also be in action as King Faisal, Okwawu United and Hasaacas all push to advance to the third round of the competition.